Abstracts by key term: Biosimilars
Biopharmaceuticals are medicines whose active ingredients are obtained as part of a genetic engineering manufacturing process using DNA recombination methods. This manufacturing process is fundamentally different from the synthesis of the active ingredients of chemical drugs. While a chemical synthesis route can be copied identically, the production of drugs from genetically modified organisms is much more complex and results in the active ingredient remaining unique and can only be imitated by another manufacturer, but not reproduced identically. For this reason, copycat biopharmaceuticals are referred to as biosimilars and not as generics, as is the case with chemical medications. In the next few years, a number of biopharmaceuticals will lose their exclusivity, so new biosimilars are likely to complement the biosimilar market, which is currently limited to three drug groups. Even if this can result in cost savings for the payers, it is not possible to validly forecast market developments.
24.01.2013
In recent years, the use of biotechnologically produced drugs has increased significantly. These active ingredients, which are usually produced through the use of bacteria or cell cultures, are used in a variety of indication areas. Biotechnologically produced active ingredients are used particularly in the treatment of serious diseases such as anemia in kidney disease, rheumatoid arthritis and other systemic diseases as well as various cancers (Roger 2006). One way to save costs in the area of biologicals is to increase the use of so-called “biosimilars”, which can be developed by other manufacturers and brought onto the market after the patent protection of the biological has expired. As part of a model calculation, it was examined how high these expected savings could be by substituting the reference biologicals with biosimilars using the example of selected European countries between 2007 and 2020.