Abstracts by key term: Drug therapy safety
Die HARM-Studie (2011) belegte erstmals in Europa den signifikanten Zusammenhang zwischen Medikationsfehlern und vermeidbaren Krankenhausaufnahmen (1, 2). Seither steht die Arzneimitteltherapiesicherheit (AMTS) im Fokus. Zentrale Hürden sind hierbei arzneimittelbezogene Probleme (ABP) – Ereignisse, die Therapieziele gefährden (z. B. Interaktionen, Dosierfehler, Nebenwirkungen) (3). Die Prävalenz von ABP steigt massiv bei älteren, multimorbiden Patientinnen und Patienten mit Polymedikation (4–6). […]
03.08.2026
Medicines are effective and efficient as a form of therapy in the outpatient and inpatient care of patients, provided they are used correctly. However, with increasing therapy options through new drug developments and the simultaneous use of several drugs (polypharmacy), the complexity of drug therapy increases. In particular, chronically ill and multimorbid patients are often treated with several different medications, which increases the risk of adverse drug reactions (ADRs) and drug-related harm. The risk of ADRs in these patients increases due to age-associated changes in pharmacokinetics and pharmacodynamics, in addition to potential drug interactions. Ensuring drug therapy safety (AMTS), especially for chronic patients, represents a particular challenge in drug supply.