Study shows superior efficacy of Ciclopoli against nail fungus
07.04.2015 11:40
The complete cure rate of Ciclopoli against nail fungus (35%) is three times higher compared to an Amorolfine 5% nail polish (11.7%) - this is the result of a current head-to-head study that was presented at this year's EADV spring symposium in Valencia . The authors were the first to compare the effect of medical nail polish with the active ingredients ciclopirox and amorolfine. For this purpose, two groups of patients with onychomycosis were treated for 48 weeks. It also showed that the responder rate* was significantly superior to the water-soluble nail polish Ciclopoli against nail fungus with the active ingredient Ciclopirox, with a success rate that was twice as high.
Ciclopoli wins the direct comparison
In the randomized study, 120 patients with mild to moderate onychomycosis were divided into two groups and the evaluation was blinded. One group applied the nail polish Ciclopoli, which contains ciclopirox, every day to treat nail fungus; the other group applied a reference varnish containing amorolfine twice a week. The application was carried out according to the instructions for use.
The study data shows: A clear superiority of Ciclopoli against nail fungus compared to the reference varnish can be observed after just 24 weeks. This applies to both the healing rate and the responder rate and continues over the further period of use. After 48 weeks of treatment, 58.3 percent of Ciclopoli users show almost healthy nail growth and mycological healing. This means you achieve statistically significant superiority over the comparison group with 26.7%.
Unique galenics and easy application
The high effectiveness of water-soluble nail polishes is due, among other things, to the unique varnish base. The hydroxypropyl chitsoan (HPCH) it contains binds to the nail keratin and thus transports the active ingredient deep into the nail. The water-soluble varnish Ciclopoli against nail fungus penetrates the nail significantly faster and in a higher concentration than a reference varnish containing amorolfine. In addition, HPCH stabilizes the nail through its binding properties and promotes healthy nail growth.
Another advantage of water-soluble anti-fungal varnishes is their ease of application. The polish is brushed onto the nail in the evening before going to bed. The nail polish is absorbed overnight and transports the antifungal active ingredient ciclopirox deep into the nail. Paint residue can simply be washed off with water the next morning. There is no need to file the nail plate or remove it with solvents.